Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

    Andrew P. Latham, Longchen Zhu ... Bin Zhang
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

    Natalia E Ketaren, Fred D Mast ... John D Aitchison
    High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.
    1. Biochemistry and Chemical Biology

    Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

    Benjamin R Duewell, Naomi E Wilson ... Scott D Hansen
    Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P3 production during immune cell signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

    Marian Brenner, Christoph Zink ... Antje Gohla
    1. Biochemistry and Chemical Biology

    Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309

    Zheng Ruan, Junuk Lee ... Wei Lü
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S. Haugerud ... Christoph A. Weber
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodelling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher T. A. Lewis, Elise G. Melhedegaard ... Julien Ochala
    1. Biochemistry and Chemical Biology

    Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

    George N. Bendzunas, Dominic P Byrne ... Natarajan Kannan
    1. Biochemistry and Chemical Biology

    Probing PAC1 receptor activation across species with an engineered sensor

    Reto B. Cola, Salome N. Niethammer ... Tommaso Patriarchi
    1. Biochemistry and Chemical Biology

    ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

    Aleksandar Bartolome, Julia C. Heiby ... Alessandro Ori
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors